Vaccine TopicsMeasles-Mumps-Rubella VaccineVaccine Information Statement NewsMay 26, 2010 -- The Bureau of Immunization is pleased to highlight the recent publication of the measles-mumps-rubella-varicella (MMRV) interim Vaccine Information Statement (VIS). The MMRV interim VIS dated 5/21/2010 is now available. It is the preferred VIS for children getting MMRV vaccine, as it contains more detailed information about the risk of febrile seizures. Details can be found on the "VIS News" webpage: www.cdc.gov/vaccines/pubs/vis/vis-news.htm. Healthcare providers should periodically access the VIS electronically and print out a supply for routine distribution. If necessary, Bureau staff can FAX copies to providers without internet access. Links to the latest VIS can be found at:
ACIP Recommendations for Use of Combination Measles-Mumps-Rubella-Varicella VaccineMay 13, 2010 -- The Bureau of Immunization is pleased to bring to your attention an important report published by the Centers for Disease Control and Prevention (CDC) on May 7, 2010, in the Morbidity and Mortality Weekly Report (MMWR Weekly / Vol. 59 / No. RR3). The report, Use of Combination Measles, Mumps, Rubella, and Varicella Vaccine - Recommendations of the Advisory Committee on Immunization Practices (ACIP) (page 1 - 12), presents the recommendations and use of the combination measles-mumps- rubella-varicella vaccine (MMRV, ProQuad, Merck & Co., Inc.). We encourage providers to read these recommendations and guidance carefully, since we include only excerpts here. In June 2009, the CDC's Advisory Committee on Immunization Practices (ACIP) adopted new recommendations regarding use of the combination MMRV vaccine. MMRV vaccine was licensed in the U.S. in September 2005 and may be used instead of measles-mumps-rubella vaccine (MMR, M-M-RII, Merck & Co., Inc.) and varicella vaccine (VARIVAX, Merck & Co., Inc.) to implement the recommended 2-dose vaccine schedule for prevention of measles, mumps, rubella, and varicella among children 12 months through 12 years of age. At the time of its licensure, use of MMRV vaccine was preferred for both the first and second doses over separate injections of equivalent component vaccines (MMR vaccine and varicella vaccine), which was consistent with the ACIP's 2006 general recommendations on use of combination vaccines (CDC. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2006;55;[No. RR-15]). Since July 2007, supplies of MMRV vaccine have been temporarily unavailable as a result of manufacturing constraints unrelated to efficacy or safety. MMRV vaccine is now available in the U.S. again. After consideration of the postlicensure data and other evidence, the ACIP adopted the following summized new recommendations regarding use of MMRV vaccine for the first and second doses and identified a personal or family (i.e., sibling or parent) history of seizure as a precaution for use of MMRV vaccine:
MMRV vaccine may be administered simultaneously with other vaccines recommended for children 12 to 15 months of age and 4 to 6 years of age. If simultaneous administration is not possible, MMRV vaccine may be administered at any time before or after an inactivated vaccine but at least 28 days before or after another live, attenuated vaccine, except varicella vaccine, for which a minimum interval of 3 months is recommended. Effective Monday, May 10, 2010, Merck ProQuad, MMR-V, NDC 00006-4999-00, 10-pack single dose vial became available for ordering through the Vaccines for Children (VFC) Program. A separate Vaccine Information Statement (VIS) for MMRV is in draft form and is expected to be available later this year. Both MMR and varicella VISs include information about MMRV and are available at: http://www.cdc.gov/vaccines/pubs/vis/. CDC Health Alert: Travel Notice During Multi-State Mumps OutbreakMarch 12, 2010 -- The Bureau of Immunization is pleased to bring the following Health Alert Network (HAN) message to your attention. A multi-state mumps outbreak is occurring primarily among the Hasidic (Jewish) population residing or attending school in the New York and New Jersey areas. A mumps outbreak affecting this same population is also ongoing in Israel. The onset of Pesach (Passover) may represent new opportunities for mumps transmission as people travel for the holiday, especially March 30 through April 5, 2010. You may have vulnerable populations in your community.
Update: Measles: United States, January through July 2008August 25, 2008 -- The Florida Department of Health, Bureau of Immunization announces publication of the Centers for Disease Control and Prevention's (CDC), Morbidity and Mortality Weekly Report (MMWR); August 22, 2008 / 57(33);893-896 - Update: Measles --- United States, January--July 2008. During January through July 2008, 131 measles cases were reported to the CDC, compared with an average of 63 cases per year during 2000-2007. This report updates an earlier report on measles in the United States during 2008 and summarizes two recent U.S outbreaks among unvaccinated school-aged children. Among those measles cases reported during the first 7 months of 2008, 76% were in persons less than 20 years of age, and 91 percent were in persons who were unvaccinated or of unknown vaccination status. Of the 131 cases, 89% were imported from or associated with importations from other countries, particularly countries in Europe, where several outbreaks are ongoing. The findings demonstrate that measles outbreaks can occur in communities with a high number of unvaccinated persons and that maintaining high overall measles, mumps, and rubella (MMR) vaccination coverage rates in the U.S. is needed to continue to limit the spread of measles. Of particular interest is figure 2, showing that from January until July 2008, 2/3 of measles cases in the U.S. occurred in persons who were not immunized due to religious or philosophical exemption. Fact Sheet and Talking Points: Measles United States, January 1 - April 25, 2008The Florida Department of Health, Bureau of Immunization announces publication of the Centers for Disease Control and Prevention (CDC), Morbidity and Mortality Weekly Report (MMWR) Early Release 2008; volume 57; 1-4 on May 1, 2008, concerning important information regarding measles outbreaks in the U.S. The outbreak information includes 64 measles cases in 9 states, with outbreaks in 4 states from January 1 through April 24, 2008. While none of the cases are in Florida, a number of county health departments are conducting surveillance with contacts to the cases referenced in the attachment. These cases and outbreaks resulted primarily from failure to vaccinate, many because of personal or religious belief exemption. This fact highlights:
Transmission has occurred in community and healthcare settings, including homes, childcare centers, schools, hospitals, emergency rooms, and physicians’ offices. The majority of cases are associated with importation from other countries. Immunization with the measles-mumps-rubella (MMR) vaccine is the most effective preventive measure. Unless there is other evidence of measles immunity, two doses of MMR vaccine are recommended for all school students, students in post–high school educational facilities, healthcare personnel, and international travelers who are older than 12 months of age (NOTE: infants 6 to 11 months of age should receive one dose prior to travel abroad). The MMWR: Measles --- United States, January 1--April 25, 2008 can be accessed at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm57e501a1.htm. Further information is available in the CDC Fact Sheet: Measles, United States, January 1--April 25, 2008 [PDF 91 KB]. The MMWR can be accessed on the web at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5733a1.htm?s_cid=mm5733a1_e. |
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